Science
Senolytics
Clearing worn-out cells that stop dividing but keep signalling inflammation.
What it is
Senescent cells accumulate with age and secrete inflammatory factors. Senolytics aim to remove them selectively. The field's challenge has been achieving selectivity without systemic toxicity.
Key mechanisms and technologies
- BCL-2 family inhibitors
- Prodrug activation
- Immune-mediated clearance
- Senescence biomarkers
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