Track the science, companies and market developments shaping the future of human longevity.
Science Clinical Biotech Markets
Every development traces to its source.
Scientific strength is evaluated in context.
Science is connected to relevant companies.
Advanced AI, proprietary algorithms and expert analysis work together to identify, structure and interpret developments across science and markets.
A peer-reviewed analysis proposes that therapeutic strategies for immunosenescence should shift from trying to restore a youthful gut microbiome toward targeting specific host-sensing pathways and microbial functional outputs.
Past 7 days · Newest first
The discovery of PLA2G7 as a negative regulator of dentate gyrus synaptic function reveals a novel target for reversing age-related cognitive decline through neural stem cell lipid modulation.
A prospective analysis published in Geroscience reports that baseline levels of plasma neurodegeneration biomarkers do not predict short-term physical decline in older adults, though longitudinal changes in the NT1 biomarker correlate with changes in grip strength.
A newly published scientific review highlights the Hippo-YAP/TAZ signaling pathway as a central regulator of brain aging and neurodegeneration, suggesting its potential as a novel disease-modifying therapeutic target.
Researchers developed a protease-resistant D-amino acid mini-chaperone peptide that extends lifespan and reduces amyloid-beta toxicity in C. elegans, offering a potential therapeutic approach for protein-misfolding diseases.
A newly published scientific review delineates the molecular drivers of age-associated sinoatrial node degeneration, pointing to senolytic, gene-based, and regenerative therapies as future alternatives to permanent pacemakers.
A systematic review in Ageing Research Reviews outlines the neuroprotective mechanisms of caloric and dietary restriction, emphasizing the potential of targeting autophagy, neuroinflammation, and nutrient-sensing pathways in neurodegenerative diseases.
A newly published review in Ageing Research Reviews synthesizes evidence showing that chrononutrition interventions, including time-restricted eating, improve metabolic resilience and modulate core biological aging pathways such as autophagy and nutrient sensing.
Researchers engineered a dual-gated DNA nanoplatform that selectively suppresses SASP in therapy-induced senescent tumor cells via NF-κB blockade and promotes M1 macrophage polarization in vivo.
A systematic review outlines how the ubiquitin-proteasome system governs auditory proteostasis and proposes targeting this pathway to address sensorineural hearing loss.
A peer-reviewed literature review delineates the distinct roles of immunosenescence, inflammaging, and cellular senescence in rheumatoid arthritis, highlighting that therapeutic evidence for senolytics remains confined to non-RA models.
An in vitro study demonstrated that a proprietary Hydrolyzed Yeast Protein Extract acts as a SIRT6 activator in human skin cells, reducing cellular hallmarks of aging such as DNA damage and telomere attrition to support its potential integration into topical anti-aging formulations.
A comprehensive literature review highlights epigenetic dysregulation and epigenetic aging as central intermediaries connecting diabetes and cancer, providing a biological framework for therapeutic interventions targeting shared metabolic-epigenetic pathways.
Preclinical research demonstrates that while metformin exhibits partial senomorphic activity by reducing cellular senescence markers, it does not prevent functional sensory deficits in a rat model of cisplatin-induced peripheral neuropathy.
A mouse model study shows that chronic mild stress accelerates systemic inflammaging and tissue-specific mitochondrial damage, both of which are mitigated by NMN and the Bazi Bushen formula via AMPK-Sirtuins pathway activation.
Researchers reported that genetic modifiers impact beta cell regulation of retinoic acid signaling and circadian entrainment to modulate beta cell senescence and diabetes penetrance in mice modeling monogenic diabetes.
Researchers identified that resveratrol delays knee osteoarthritis progression in animal models by regulating inflammatory cytokines and suppressing the FoxO and IL-17 signaling pathways.
A newly proposed systems-level framework, the Aging Purinome, models how age-associated remodeling of extracellular purinergic signaling and NAD+ metabolism drives sterile inflammation, providing a structured basis for drug discovery.
A study published in Human Reproduction demonstrates that FSP1+ stromal cells drive GAS6-MERTK-mediated macrophage efferocytosis and subsequent TNF-α-induced stromal cell senescence, identifying a potential target pathway for treating decidualization impairment in adenomyosis.
A Nature Aging study reveals that male-biased naive CD8+ T cell depletion and thymus involution impair cancer antigen recognition, which can be reversed therapeutically via thymus regeneration.
Researchers have identified placenta-derived CXCL1 as a key senescence-associated secretory phenotype (SASP) factor mediating gestational cadmium-induced fetal renal dysplasia, presenting a novel therapeutic target for developmental pathologies driven by cellular senescence.
Researchers reported that exposure to the environmental pollutant tributyl phosphate accelerates liver senescence in animal and cell models through a pathway involving fumarate accumulation, mitochondrial DNA leakage, and FPR2 activation.
A new review in Human Reproduction Update outlines how systemic and local immune dysregulation drive ovarian decline, suggesting that targeting the immune-ovarian axis could provide therapeutic avenues for extending female reproductive lifespan.
Researchers discovered that knocking down the neuronal GPCR gtr-1 in C. elegans mitigates Aβ amyloid toxicity and enhances distal protein degradation, revealing a GPCR-mediated neuropeptide signaling pathway that could serve as a systemic therapeutic target for neurodegenerative proteinopathies.
A retrospective study of 109,224 Danish cancer survivors shows that therapy-related accelerated aging is exacerbated by social determinants of health, particularly lower educational attainment.
A study in mouse models and primary hepatocytes published in Diabetes, Obesity and Metabolism reports that autophagy maintains Foxo1 protein abundance via amino acid homeostasis to support glucagon-mediated hepatic glucose production during fasting.
A large-scale analysis of UK Biobank data demonstrates that higher Brain Care Scores are associated with thicker neuroretinal layers and a younger retinal biological age, supporting the use of optical coherence tomography as a non-invasive biomarker of systemic and brain aging.
A newly published scientific review re-evaluates enzymatic protein repair as a distinct component of proteostasis, linking the progressive failure of these pathways to the development of major age-related diseases.
A preclinical study published in the American Journal of Veterinary Research reports that kinetin partially reverses D-galactose-induced thymic lymphocyte dysfunction in rats by preserving mitochondrial membrane potential and regulating apoptosis-related gene expression.
Lineage tracing of oocyte development in mice reveals that heterogeneity in growing follicles forms a secondary ovarian reserve, uncovering a biological buffering mechanism that sustains female fertility across the reproductive lifespan.
A newly published review outlines how age-related impairments in microglial lipid handling and organelle crosstalk prime the aging brain for perioperative neurocognitive disorders, highlighting TREM2 and FADS1 as high-priority therapeutic targets.
