Science

mTOR

A cellular growth switch that, when dialled down, extends life in animals.

What it is

mTOR inhibition is the most reproducible lifespan intervention in model organisms. Human translation has repeatedly failed on clinical endpoints, making selectivity and endpoint choice the decisive variables.

Key mechanisms and technologies

Rapalogs
Selective TORC1 inhibition
Intermittent dosing

Published LONGEFI developments are listed chronologically in the News archive.