Page 4 of 11 — 256 published developments, newest first.
A systematic review in Aging Cell identifies mitochondrial fission and fusion dynamics as a shared therapeutic target for age-related cardiac and neurodegenerative diseases, highlighting potential intervention pathways like SGLT2 inhibitors and NAD+ precursors.
Read analysisA peer-reviewed study reports that patients with primary sclerosing cholangitis and primary biliary cholangitis show accelerated biological aging and telomere attrition, which directly correlate with disease severity and liver cirrhosis.
Read analysisResearchers identified Krüppel-like factors as upstream regulators of lipid homeostasis that modulate SKN-1/Nrf activity, establishing a physiological link between lipid metabolism, stress resistance, and longevity in C. elegans.
Read analysisA peer-reviewed study outlines how berberine acts as a pleiotropic modulator of aging hallmarks, including AMPK activation and cellular senescence, illustrating growing academic interest in multi-target geroprotective compounds.
Read analysisA new framework published in The Lancet Healthy Longevity proposes that sarcopenia is a manifestation of systemic energetic failure rather than isolated muscle tissue degeneration, indicating that future therapeutic interventions must target integrated physiological systems.
Read analysisPreclinical research published in Molecular Biology Reports demonstrates that shikonin improves redox and mitochondrial homeostasis to protect against doxorubicin-induced cardiac aging and fibrotic remodeling in rats.
Read analysisA 9-year longitudinal study of older cyclists demonstrates that continuous high-level exercise maintains physiological function far superior to general reference populations but cannot fully halt age-related declines in V̇O2peak and lean muscle mass.
Read analysisA newly published literature review indicates that while diet-induced metabolic shifts alter brain substrate availability, they do not consistently restore the coordinated neuroenergetic flexibility lost during aging.
Read analysisA systematic review of 41 preclinical studies establishes that while mild caloric restriction of less than 40% improves emotionality in rodents, severe restriction of 40% or more triggers anxiety-like behaviors.
Read analysisA new experimental model reveals that the health effects of supplemental lysine in older adults are highly context-dependent, governed by interactions between senescent digestive cells, gut microbes, and phages.
Read analysisResearchers found that Perilla frutescens extract extends lifespan and lowers lipid storage in C. elegans by modulating the insulin/IGF-1 signaling pathway and activating stress-response transcription factors.
Read analysisA systematic review in Critical Reviews in Food Science and Nutrition outlines how medium-chain triglycerides can provide alternative cerebral energy substrates, though inconsistent clinical efficacy remains a key hurdle to therapeutic translation.
Read analysisA protein-protein interaction network analysis of crocidolite-exposed lung cells demonstrated significant proximity to lung cancer modules, identifying prioritized hub genes enriched in cellular senescence pathways.
Read analysisA longitudinal study of 132 monozygotic twin pairs indicates that the apparent associations between healthy dietary patterns and decelerated epigenetic aging are heavily confounded by genetic and shared environmental factors.
Read analysisThe newly published protocol for the STRONG trial outlines a 1-year randomized controlled study to determine if daily blueberry consumption, protein supplementation, and structured exercise can reduce frailty and improve cardiovascular health in adults aged 65 and older.
Read analysisA peer-reviewed article in Pharmacology & Therapeutics details how the reactivation of transposable elements during aging drives genomic instability and chronic inflammation, positioning TE pathways as novel therapeutic targets.
Read analysisA study in Biogerontology reports that plant-derived polysaccharides from Turnera diffusa extend lifespan and mitigate metabolic decline in C. elegans and D. melanogaster by activating conserved DAF-16/FOXO and HSF-1 stress response pathways.
Read analysisA newly published scientific review outlines how stress granules and RNA-binding proteins function as context-dependent regulators of cellular senescence and the associated inflammatory secretory phenotype, defining novel potential therapeutic targets.
Read analysisResearchers found that cinnamon roll-flavored e-cigarette aerosols with nicotine induce mitochondrial DNA damage and trigger cell-death pathways in human alveolar cells, identifying potential therapeutic targets for vaping-associated lung injury.
Read analysisAn interactive art installation at UC Berkeley, inspired by a professor's survival of idiopathic pulmonary fibrosis, highlights the severe clinical burden and systemic impact of progressive lung scarring.
Read analysisThe development of P-selectin-targeted senescence-modulating nanoparticles demonstrates a highly selective method to deplete pathogenic senescent cells, offering a potential therapeutic avenue to reverse tissue fibrosis and overcome immune exclusion in oncology.
Read analysisA study of Framingham Heart Study participants found that an artificial intelligence-based biological vascular age metric correlates with subclinical brain injury and worse neuropsychological performance, suggesting a potential noninvasive biomarker for cognitive risk.
Read analysisA case-control study published in EBioMedicine demonstrates that biological ageing markers remain elevated in virologically suppressed people with HIV and correlate with advanced brain ageing and socio-environmental risk factors.
Read analysisResearchers used the generative framework AURORA to identify the oral commensal bacterium Neisseria flavescens as a geroprotective agent that decelerated aging in human profiles and extended lifespan in worm and mouse models.
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