Page 2 of 11 — 255 published developments, newest first.
A retrospective study of 109,224 Danish cancer survivors shows that therapy-related accelerated aging is exacerbated by social determinants of health, particularly lower educational attainment.
Read analysisA study in mouse models and primary hepatocytes published in Diabetes, Obesity and Metabolism reports that autophagy maintains Foxo1 protein abundance via amino acid homeostasis to support glucagon-mediated hepatic glucose production during fasting.
Read analysisA large-scale analysis of UK Biobank data demonstrates that higher Brain Care Scores are associated with thicker neuroretinal layers and a younger retinal biological age, supporting the use of optical coherence tomography as a non-invasive biomarker of systemic and brain aging.
Read analysisA newly published scientific review re-evaluates enzymatic protein repair as a distinct component of proteostasis, linking the progressive failure of these pathways to the development of major age-related diseases.
Read analysisA preclinical study published in the American Journal of Veterinary Research reports that kinetin partially reverses D-galactose-induced thymic lymphocyte dysfunction in rats by preserving mitochondrial membrane potential and regulating apoptosis-related gene expression.
Read analysisLineage tracing of oocyte development in mice reveals that heterogeneity in growing follicles forms a secondary ovarian reserve, uncovering a biological buffering mechanism that sustains female fertility across the reproductive lifespan.
Read analysisA newly published review outlines how age-related impairments in microglial lipid handling and organelle crosstalk prime the aging brain for perioperative neurocognitive disorders, highlighting TREM2 and FADS1 as high-priority therapeutic targets.
Read analysisResearchers have mapped a macrophage-orchestrated pyroptosis-senescence axis in drug-resistant benign prostatic hyperplasia, identifying GSDMD, MIF-CD74, and HMGB1-AGER as potential therapeutic targets to halt tissue remodeling.
Read analysisA scientific review suggests that targeting cellular senescence with senolytics and senomorphics could address the age-related mechanisms driving persistent vascular injury in giant cell arteritis.
Read analysisA longitudinal study published in Cell Reports Medicine demonstrates that a three-region brain aging model achieves superior mortality prediction over global brain age by linking localized structural changes to systemic immune and neurovascular pathways.
Read analysisA peer-reviewed paper clarifies how mitochondrial impairment in renal tubular epithelial cells drives kidney fibrosis, highlighting mitophagy and mitochondrial quality control as promising but clinically challenging therapeutic targets.
Read analysisA lifespan MRI study of 25,425 healthy individuals and 1,737 clinical patients demonstrates that brain-predicted age difference (brain-PAD) serves as a quantitative biomarker for accelerated brain aging in schizophrenia, frontotemporal dementia, and Alzheimer's disease.
Read analysisAn analysis published in Nature Aging shows that cross-sectional and longitudinal designs can yield divergent estimates of age-varying genetic effects on complex traits, primarily due to cohort confounding and participation bias.
Read analysisA newly published methodological review proposes an integrated, cross-scale framework to map the causal link between the mitochondria-pyroptosis inflammatory axis and age-related muscle atrophy and cognitive decline.
Read analysisResearchers identified that lipid acyl chains lengthen with age across species and that targeting the lipid-remodeling enzyme Plb1 extends lifespan in worms, highlighting lipid elongation as a novel therapeutic target.
Read analysisA clinical study published in Acta Neurologica Belgica reports that young patients with relapsing-remitting multiple sclerosis exhibit significantly shorter leukocyte telomeres independent of shelterin genetics, suggesting that chronic neuroinflammation drives premature immunosenescence.
Read analysisA cross-sectional study of laboratory Beagles mapped non-linear, sex-stratified immune aging patterns and identified rapamycin as the most active cytokine-modulating intervention among evaluated geroprotectors.
Read analysisShift Bioscience has published a peer-reviewed calibration framework to address miscalibration in deep learning genetic perturbation models, aiming to increase the reliability of AI-driven screens for cellular rejuvenation and fibrosis targets.
Read analysisAn observational study of diabetic adults aged 75 and older found that advanced chronic kidney disease and poor glycemic control are the primary drivers of hospitalization, whereas metformin and incretin-based therapies are associated with fewer hospital days.
Read analysisA systematic review in the British Journal of Clinical Pharmacology reports that while targeting cellular senescence is clinically feasible, existing human trial data are insufficient to establish efficacy or long-term safety.
Read analysisA scientific review published in Cell Chemical Biology outlines how protein arginine methyltransferases regulate immune cells and chromatin, identifying arginine methylation as a potential therapeutic target for age-associated inflammaging.
Read analysisPreclinical findings demonstrate that the kinase inhibitor sunitinib selectively clears senescent human dermal fibroblasts and reduces senescent cell burden in a mouse model of lung fibrosis via PDGFRβ modulation.
Read analysisA meta-analysis of clinical trials indicates that electroacupuncture targeting the NLRP3 inflammasome provides short-term cognitive improvements in mild cognitive impairment, though substantial methodological heterogeneity prevents verification of long-term disease modification.
Read analysisA study in Nature Aging demonstrates that age-related decline in chaperone-mediated autophagy impairs macrophage clearance of senescent cells, while restoring autophagy enhances macrophage function and reduces senescent cell accumulation.
Read analysis