Page 14 of 16 — 378 published developments, newest first.
A narrative review proposes that cellular senescence and its paracrine secretory phenotype damage cardiac lymphatic vessels, establishing a novel senescence-lymphatic axis that could be targeted with senolytic therapies to treat heart failure with preserved ejection fraction.
Read analysisA study published in GeroScience reports that rapamycin's effect on Drosophila melanogaster lifespan is highly sensitive to background diet, showing beneficial effects on a nutrient-rich medium but predominantly detrimental effects on a leaner medium.
Read analysisA newly published review synthesizes how age-associated immune decline and cellular senescence drive breast cancer progression, establishing metabolic rescue and targeted senolytics as promising clinical frontiers.
Read analysisA narrative review proposes evaluating eicosapentaenoic acid (EPA) through a peripheral-to-central resolution-biology framework to clarify clinical heterogeneity and establish rigorous biological boundaries in brain aging and mood research.
Read analysisA clinical trial (SPARC-PD) has been registered to evaluate the safety and efficacy of autologous bone marrow-derived cell and concentrate therapies delivered via intravenous and intranasal routes in patients with Parkinson's disease and Parkinson-Plus syndromes.
Read analysisA longitudinal analysis of dementia-free older adults demonstrates that cognitive aging trajectories are highly heterogeneous and strongly linked to modifiable physical metrics such as gait speed, diet, and physical activity rather than typical genetic risk factors of dementia.
Read analysisA newly proposed feed-forward amplification model of cellular senescence in posterior segment neovascular diseases establishes a mechanistic rationale for using senolytic interventions to halt retinal degeneration.
Read analysisA newly published narrative review in Biogerontology characterizes the class III histone deacetylase SIRT1 as a key neuroprotective target against brain senescence, highlighting the therapeutic potential of sirtuin-modifying compounds.
Read analysisA cross-sectional study of 4,846 Chinese middle-aged and older adults published in Frontiers in Nutrition found that Southern and Western-like dietary patterns were associated with decelerated biological aging, whereas a plant-rich diet was unexpectedly associated with accelerated biological aging.
Read analysisA literature review published in Current Opinion in Rheumatology frames systemic sclerosis as an accelerated biological aging pathology, identifying cellular senescence and mitochondrial dysfunction as key drivers of progressive tissue fibrosis.
Read analysisA review published in Frontiers in Cellular and Infection Microbiology introduces host-virus resilience networks and viral inflammaging circuits to describe how the breakdown of multi-system physiological resilience drives cytomegalovirus reactivation in aging and long COVID.
Read analysisA newly published study demonstrates that substance use—including alcohol, tobacco, and illicit drugs—alongside substance use disorder severity, is associated with accelerated epigenetic aging, highlighting the utility of epigenetic clocks in measuring toxicological impacts on biological age.
Read analysisA study published in Biogerontology reports that mutations in Drosophila PIWI subfamily genes, which increase DNA damage via hobo transposons, paradoxically extend lifespan under both control and chronic low-dose irradiation conditions.
Read analysisNiagen Bioscience reported $29.8 million in Q2 2026 net sales and appointed Dr. Abhijit Kale to lead its new pharmaceutical program, signaling a strategic transition from consumer supplements toward regulated clinical development of NAD+ precursors.
Read analysisA study published in Cell Metabolism reports that a methionine-supplemented longevity diet increases circulating levels of growth hormone, GLP-1, and FGF21, and is associated with reduced frailty and enhanced healthspan.
Read analysisA review in Aging and Disease highlights mitochondrial inflammation as a key driver of muscle aging, positioning the inflammatory microenvironment as a precise therapeutic target for sarcopenia.
Read analysisA cross-species study published in Biology Direct reports that SLC25A12 mitigates myoblast senescence and cuproptosis-related changes, identifying it as a potential therapeutic target for sarcopenia.
Read analysisA newly published academic review examines Traditional Chinese Medicine as a potential source of senolytic and senomorphic agents to target cellular senescence in the aging kidney.
Read analysisA newly published study indicates that Asiaticoside mitigates endothelial cell senescence in diabetic retinopathy through CCND1-mediated mitophagy regulated by the PI3K/AKT/mTOR pathway.
Read analysisTransient reduction of the NuA4 acetyltransferase complex during early development triggers a compensatory endoplasmic reticulum stress response and oleic acid accumulation, conferring lifelong resilience against proteotoxic stress and extending lifespan in C. elegans.
Read analysisA study in mice establishes that systemic TNF-mediated TNFR1 signaling drives intestinal stem cell aging by impairing mitochondrial fatty acid oxidation, a phenotype reversed in vivo by systemic anti-inflammatory or mitochondrial-targeted therapies.
Read analysisA scientific review published in PubMed highlights circulating extracellular vesicles as systemic mediators of cardiac aging, suggesting new biomarker and therapeutic targets for age-related cardiovascular decline.
Read analysisA scientific review published in Ageing Research Reviews outlines how clonal hematopoiesis of indeterminate potential drives cardiovascular and immune system aging, offering potential targets for systemic inflammation therapy.
Read analysisResearchers developed a simplified 11-marker physical aging clock that integrates routine biomarkers and functional performance to predict chronic disease incidence and mortality, outperforming traditional PhenoAge models.
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